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肠炎造模领域的金标准
品名：Dextran Sulfate Sodium Salt，硫酸葡聚糖钠盐
货号：0216011010
MW 36000-50000
肠炎造模研究领域的金标准------超3000篇文献支持、业界证明是非常有效
葡聚糖硫酸钠(Dextran Sulfate Sodium Salt，DSS)是葡聚糖的聚阴离子衍生物。MP独特的DSS因为其具
有非常好的质量，非常高的纯度和非常好的可重复性使其应于各个领域，包括临床，分子生物学，生
物医学甚至化妆品领域。
MP Biomedicals生产的独特的葡聚糖硫酸钠是同行科学评议刊物里应用最广的一种产品。在过去15年
里有超过3000篇科学文献引用使用了我们的DSS。因此，一旦你选择使用我们的DSS中的任何一种，
你可以对其质量、性能及有效性放心！
MP独特的葡聚糖硫酸钠具有如下特性：
水溶性聚阴离子复合物
形成无色澄清溶液，似天然粘多糖
高纯度及良好的稳定性
可被自然生态系统降解
可作为敏感性天然成分的稳定性
肠炎研究
炎症性肠病(IBD)的特征是慢性和复发性胃肠道炎症，其可增加患结肠炎相关癌症的风险。已经有几种
动物模型被用于研究肠炎，其中一个模型就是通过小鼠口服葡聚糖硫酸钠DSS的水溶液来模拟慢性肠
炎。葡聚糖硫酸钠诱发的肠炎是自发的且用于评估IBD的治疗潜力。
使用最有效的葡聚糖硫酸钠可加速你的IBD研究。MP独特的用于肠炎研究的DSS具有以下优势：
• 非常高的硫含量：19%
• 非常高的手性： +104˚比旋光度
• 非常低的pH值: 6.2 (1%水溶液)
Applications
Dextran Sulfate Sodium (DSS) which has proven to have versatile value in Biomedical/clinical research. DSS can be used to study Colitis (Inflammatory Bowel disease) as well as an antiviral as agent.
Inflammatory Bowel Disease (IBD) is characterized by chronic and relapsing inflammation of the gastrointestinal tract which is associated with increased risk of developing colitis-associated cancer. Several animal models have been used to study colitis and one such model involves the oral administration of dextran sodium sulfate (DSS) in the drinking water of mice leading to chronic colitis. This DSS induced colitis model is spontaneous and is used to assess the therapeutic potential of treatments for IBD.
Bamba et al (2012) performed a comparative analysis of 3 different DSS preparations to examine the chemical and cytotoxic properties as well as severity of colitis. Their study concluded that the DSS from MP Biomedicals induced a severe colitis as indicated by body weight transition, DAI score, colon weight/length and histological scores. This DSS is well characterized and offers the following advantages:
• Highest sulfur content – 19%
• Highest chirality - +104° of specific rotation
• Lowest pH – 6.2 at 1% solution
Product Description
Dextran sulfate is a polyanionic derivative of dextran produced by esterification of Dextran with chlorosulphonic acid. Dextran sulfate sodium (DSS) is the sodium salt which is a white to off-white powder freely soluble in water and salt solutions to form a stable, clear solution. The sulfur content is approximately 17% which corresponds to an average of 1.9 sulfate groups per glucosyl residue of the dextran molecule.